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Researchers Identify New Genes Linked With Schizophrenia Risk in First-of-Its-Kind Study

Researchers have made an important discovery about the causes of schizophrenia, a disease related to dementia or fragmented mentality.   Researchers have identified two genes associated with the disease as well as a third gene that carries the risk of schizophrenia and autism. Scientists involved in this research believes, this discovery can go a long way in finding a cure for these kind of diseases. Researchers at the Icahn School of Medicine found that these harmful genes are almost the same in every ethnic or racial group. The findings of this research were published in Nature Genetics . According to an estimate, about one percent of people worldwide suffering from schizophrenia. The scientists identified two risky genes, SRRM2 and AKAP11, based on a comparative analysis of gene sequencing from individuals with schizophrenia and healthy individuals. It compared a dataset of 35,828 patients with schizophrenia to 107,877 healthy or control groups and included a variety of
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Researchers Identify New Genes Linked With Schizophrenia Risk in First-of-Its-Kind Study

Researchers have made an important discovery about the causes of schizophrenia, a disease related to dementia or fragmented mentality.  

Researchers have identified two genes associated with the disease as well as a third gene that carries the risk of schizophrenia and autism. Scientists involved in this research believes, this discovery can go a long way in finding a cure for these kind of diseases.

Researchers at the Icahn School of Medicine found that these harmful genes are almost the same in every ethnic or racial group. The findings of this research were published in Nature Genetics. According to an estimate, about one percent of people worldwide suffering from schizophrenia.

The scientists identified two risky genes, SRRM2 and AKAP11, based on a comparative analysis of gene sequencing from individuals with schizophrenia and healthy individuals. It compared a dataset of 35,828 patients with schizophrenia to 107,877 healthy or control groups and included a variety of ethnic groups.

Recent studies have identified 8 genes as a risk factor for schizophrenia, they are mainly found in people of European white population but this study found these common genes in different ethnic groups.

According to study author Dongjing Liu, focusing on a subclass of genes, various variants were discovered that could prove helpful in better treatment of schizophrenia. Studies of people with different ancestral backgrounds have found that these deleterious rare variants of the gene lead to similar risk of schizophrenia in different groups during development.

Furthermore, it was also found that the PCLO gene, which was previously thought to cause only schizophrenia, is also responsible for autism. According to co-senior author Alexander W. Charon, associate professor at Icahn Mount Sinai, the findings also reflect changes in how brain diseases are thought of.

The gene may be clinically different in the same family. A variant of a gene can cause autism in a person while another member of the same family may have schizophrenia with the same variant. This information can provide a new way of treatment for schizophrenia and autism.

These are Key Symptoms of Schizophrenia

● Symptoms of schizophrenia usually begin to appear in adolescence or early 20s.

● Schizophrenia patient is unable to focus on anything. Not getting enough sleep causes problems in studies.

● Schizophrenia patients create an imaginary world and start making distance from the real world. Due to this, there are changes in their feelings, behavior and abilities.

● These people are not able to express their feelings properly. Get very emotional about something.

● Sometimes such things are seen or felt which are not really there.

● They are victims of delusion and many times they start believing that they have divine powers.

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