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Researchers Identify New Genes Linked With Schizophrenia Risk in First-of-Its-Kind Study

Researchers have made an important discovery about the causes of schizophrenia, a disease related to dementia or fragmented mentality.   Researchers have identified two genes associated with the disease as well as a third gene that carries the risk of schizophrenia and autism. Scientists involved in this research believes, this discovery can go a long way in finding a cure for these kind of diseases. Researchers at the Icahn School of Medicine found that these harmful genes are almost the same in every ethnic or racial group. The findings of this research were published in Nature Genetics . According to an estimate, about one percent of people worldwide suffering from schizophrenia. The scientists identified two risky genes, SRRM2 and AKAP11, based on a comparative analysis of gene sequencing from individuals with schizophrenia and healthy individuals. It compared a dataset of 35,828 patients with schizophrenia to 107,877 healthy or control groups and included a variety of
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Insomnia-Related Complaints Are Found In About Half of the Heart Disease Patients

Along with heart disease, there is also an increase in many types of health related problems. A lot of research has also been done about that. A recent research study has found that almost 50% of heart patients suffer from insomnia.

This research was published in the journal 'Sleep Advances'. Lars Frojd, a medical student at the University of Oslo and lead author of the paper, said: 'There is a general belief that sleep disturbances are associated with mental health, but we found in our study that if we also include factors such as anxiety and depression. Still, sleeplessness is more related to heart disease.

This study cautions that insomnia should also be taken care in the treatment of heart patients and adequate management should also be needed for it.

He told that in this study 1,068 people who had undergone heart attack or bypass surgery were followed up for 6 months. 

During this, data was collected about sleeplessness, a repeat factor of cardiovascular problems, and the presence of both conditions.

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The people in the research were asked common questions about sleeplessness, which included the ability to sleep and hours, waking up before the end of sleep, feeling of not getting enough rest, not working properly due to fatigue during the day  things like being unable to do, and dissatisfaction with the sleep.

Factors such as C-reactive protein (marker of inflammation), smoking status, low-density lipoprotein, cholesterol, diabetes, physical activity, systolic blood pressure were also included in their risk factors.

In addition, the effect of conditions such as stroke, transient ischemic attack (a stroke-like condition occurs for a short time), peripheral artery and kidney failure was also examined.

In addition, patients' Major Adverse Cardiovascular Events (MACE) information was collected, including data on cardiovascular death, hospitalization, stroke, and heart failure.

About 21 percent of the participants in this study were women whose average age was 62 years. About half of these women had complaints of sleeplessness and 24 percent of them used sleeping pills. In a follow-up of approximately 4.2 years, 364 events of MACE were observed in 225 patients. The situation was almost the same in men as well.

At the same time, it was also found that in those who did not have a state of sleeplessness, the relative chance of MACE recurrence was 1.68 percent. There is also evidence that there was an association between insomnia and MACE, even after including symptoms of anxiety and depression.

Insomnia accounted for 16 percent of the risk factors for MACE recurrence, second only to smoking and low physical activity.

Dr Frojd meant that participants could have reduced adverse cardiovascular events by 16 percent if there were no complaints of insomnia.

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