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Researchers Identify New Genes Linked With Schizophrenia Risk in First-of-Its-Kind Study

Researchers have made an important discovery about the causes of schizophrenia, a disease related to dementia or fragmented mentality.   Researchers have identified two genes associated with the disease as well as a third gene that carries the risk of schizophrenia and autism. Scientists involved in this research believes, this discovery can go a long way in finding a cure for these kind of diseases. Researchers at the Icahn School of Medicine found that these harmful genes are almost the same in every ethnic or racial group. The findings of this research were published in Nature Genetics . According to an estimate, about one percent of people worldwide suffering from schizophrenia. The scientists identified two risky genes, SRRM2 and AKAP11, based on a comparative analysis of gene sequencing from individuals with schizophrenia and healthy individuals. It compared a dataset of 35,828 patients with schizophrenia to 107,877 healthy or control groups and included a v...
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The Curcumin Found in Turmeric is Very Beneficial for The Tissues and Blood Vessels

A lot of information has come to the fore about the medicinal properties of turmeric. Now a research from the University of California states that the curcumin found in turmeric can prove to be very beneficial in the development of artificial blood vessels and tissues.

The research findings were published in the journal ACS Applied Materials and Interfaces. From this study, it is indicated that the bioengineers at Riverside will soon be able to develop blood vessels and tissues in the laboratory. As a result of this achievement, it will be easier to replace or regenerate damaged tissue in humans.

Curcumin has antioxidant properties that have anti-inflammatory properties also. It is also known to reduce angiogenesis in cancerous tumors. But magnetic hydrogels containing curcumin-coated nanoparticles enhance the growth-promoting secretion of vascular endothelial.

Actually, the possibility of using curcumin in vascular regeneration was already being expressed. But no concrete study in this regard has been completed so far.

A team of researchers led by Hunan Lui, professor of bioengineering at UCR's Marlon and Rosemary Bourns College of Engineering, studied curcumin's regenerative properties. 

For this, this compound was made compatible with organic hydrogels by coating it with magnetic iron oxide.

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Bioengineers at UC Riverside have now discovered that this multifunctional compound was also effective in increasing vascular endothelial growth factor (VEGF) when curcumin was delivered to stem cell cultures via magnetic hydrogels. Due to which the development of vascular tissue was accelerated.

When inserted into a culture of stem cells extracted from bone marrow, the magnetic hydrogel slowly secreted curcumin without damaging the cells. Hydrogels containing curcumin coated nanoparticles secreted higher amounts of VEGF than Ware hydrogels containing nanoparticles.

Changlu Zhu, co-author of this study, said, 'This research has proved that curcumin, secreted from magnetic hydrogel, catalyzes cells to secrete VEGF'. It also plays the role of an important growth factor in the formation of new blood vessels.

The researchers also investigated whether nanoparticle magnetism could direct nanoparticles to desired locations in the body. To test this, they delivered curcumin-coated nanoparticles through a tube to the back of fresh pig tissue and successfully guided the movement through a magnet.

This research has raised the possibility that this method can be used to treat damaged tissue or to help those tissues regenerate there to the desired location. Liu also got the support of his students at UC Riverside in this research.

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